Spider-Man is able to utilize his spider powers to traverse the environments, being able to crawl on walls and ceilings, swing short distances and instantly zip between certain points.

The player must retry the current level if Spider-Man runs out of health, falls off a building or fails to complete certain objectives such as rescuing a hostage. The game has the player controlling Spider-Man as he goes through each level, either trying to reach the exit or complete a certain objective. It was followed by three sequels in 2001: the Game Boy Color-exclusive Spider-Man 2: The Sinister Six, developed by Torus Games the PlayStation-exclusive Spider-Man 2: Enter Electro, developed by Vicarious Visions and the Game Boy Advance-exclusive Spider-Man: Mysterio's Menace, also developed by Vicarious Visions. Spider-Man received an overall generally positive reception.

The game features narration from co-creator Stan Lee, and is the first Spider-Man game published by Activision following their acquisition of the license, which would expire in 2014. Numerous villains from the comics appear as bosses, including Scorpion, Rhino, Venom, Mysterio, Carnage, and Doctor Octopus, as well as a Carnage symbiote-possessed Doctor Octopus named Monster-Ock, who was created exclusively for the game as the final boss. The game's story follows Spider-Man as he attempts to clear his name after being framed by a doppelgänger and becoming a wanted criminal, while also having to foil a symbiote invasion orchestrated by Doctor Octopus and Carnage. The game was later ported by different developers to various systems, including the Game Boy Color and Nintendo 64 that same year, as well as the Dreamcast and Microsoft Windows in 2001. It was developed by Neversoft and published by Activision using the Tony Hawk's Pro Skater game engine for the PlayStation 1. Spider-Man is a 2000 action-adventure video game based on the Marvel character Spider-Man.

Spider man 2000 pc cover art